• The Minnesota Timberwolves waived oft-injured center Nikola Pekovic. About 627 days ago Associated Press • Minnesota center Nikola Pekovic still can't run without pain in his right ankle, so there's a good chance he will retire. About 801 days ago ESPN.com ESPN.com • Minnesota Timberwolves center Nikola Pekovic will not play in 2016-17 as he continues to deal with ankle and Achilles injuries. About 895 days ago ESPN.com news services • Minnesota may keep one of the training camp invitees on the roster after the retirement of Kevin Garnett and season-ending injury to Nikola Pekovic.

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About 895 days ago ESPN.com ESPN.com • Timberwolves backup center Nikola Pekovic is still having issues with his sore ankle and Achilles. About 899 days ago ESPN.com ESPN.com • The Minnesota Timberwolves say Nikola Pekovic is out indefinitely as he recovers from right Achilles surgery he underwent last April. About 1111 days ago Associated Press • Led by the young guns and guided by the wise veterans, the Timberwolves' rebuilding plan is starting to show signs of long-term progress. About 1209 days ago Zach Lowe ESPN.com • The Minnesota Timberwolves have hired former Detroit Pistons physical therapist Arnie Kander to head their revamped athletic training staff.

About 1272 days ago Associated Press • Check out our player scouting reports and 2015-16 projections for the Timberwolves. About 1304 days ago Kevin Pelton ESPN Insider • Minnesota Timberwolves owner Glen Taylor stood at the podium and used the words 'gold standard' and 'radical departure from the norm' to describe the team's glimmering new practice facility, as N about 1361 days ago Associated Press •.

Chikungunya virus (CHIKV) is an Alphavirus that causes chronic and incapacitating arthralgia in humans. Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV is not completely defined. The macaque model of CHIKV infection was established due to limitations of clinical specimens. More importantly, its close relation to humans will allow the study of chronic infection and further identify important CHIKV targets.

In this study, serum samples from CHIKV-infected macaques collected at different time-points post infection were used to characterize the antibody production pattern and kinetics. Results revealed that anti-CHIKV antibodies were neutralizing and the E2 glycoprotein, Capsid, nsP1, nsP3 and nsP4 proteins were targets of the anti-CHIKV antibody response in macaques. Furthermore, linear B-cell epitopes recognized by these anti-CHIKV antibodies were identified, and mapped to their structural localization. This characterizes the specificity of anti-CHIKV antibody response in macaques and further demonstrates the importance of the different regions in CHIKV-encoded proteins in the adaptive immune response.

Information from this study provides critical knowledge that will aid in the understanding of CHIKV infection and immunity, vaccine design, and pre-clinical efficacy studies. Introduction Chikungunya virus (CHIKV) was first described during an epidemic in 1952 in Tanzania, East Africa as the causative agent of Chikungunya fever (CHIKF),.

CHIKV belongs to the genus Alphavirus of the family Togaviridae and is an enveloped virus with a single-stranded positive-sense RNA genome. The 12kb RNA genome is capped at the 5′ end and polyadenylated at the 3′ end and consists of two open reading frames coding for four non-structural proteins (nsP1–4), three major structural proteins (Capsid, E1, and E2) and two small cleavage products (E3 and 6K),. The E1 and E2 glycoproteins form heterodimers that associate as trimeric spikes on the virion surface while E3 and 6K were demonstrated to act as helper proteins in the budding and maturation process of the virion envelope –. In the last decade, multiple CHIKF epidemics have occurred in East Africa, the Indian Ocean Islands, and many parts of South East Asia –. More recently, new episodes of CHIKF have been reported in the Americas, further broadening the geographical spread of the disease. The Aedes species of mosquito has been the major arthropod vector associated with CHIKV transmission to humans.